Modafinil 200 mg is a benzhydryl sulfinyl acetamide compound that is structurally unrelated to and pharmacologically distinct from central nervous system stimulants such as dextroamphetamine and methylphenidate. Its primary pharmacological activity is to promote wakefulness. In clinical studies of narcolepsy patients, 200 mg or 400 mg of modafinil administered once daily resulted in clinically significant improvement compared with placebo on standard measures of wakefulness (MWT), sleepiness, and the FOSQ subscales for vigilance, general productivity, and activity but not social outcome or intimacy.
Neither a change in ESS score nor a reduction in the frequency of daytime napping was observed. The clinical benefit of modafinil 200 was independent of baseline sleep apnea severity and was maintained during the 40-week trial period.
The most common adverse events were infection, headache, and nervousness. Infection was more common in the group that received the 200 mg dose, but the difference was not statistically significant. Modafinil was well tolerated at all dosages in the narcolepsy study. It was also well tolerated in a long-term open-label extension study of patients who participated in the four-week OSA study, where improvements in objectively measured wakefulness and quality of life were maintained for 12 weeks after discontinuation of Modafinil 200 mg.
It is important to remember that while modafinil reduces sleepiness, it does not cure your condition. It is important to continue to follow your doctor’s advice about getting enough sleep and continuing to use your other treatments, such as CPAP for sleep apnea. Also, be sure to tell your doctor and pharmacist about all other medicines you are taking, including prescription and over-the-counter medicines, vitamins, and herbal products.
If you have narcolepsy or shift work disorder, your doctor will probably advise that you take your dose one hour before you start your shift. If you have obstructive sleep apnea, your doctor may advise that you take your dose before bedtime. In either case, you should always take the Modalert Australia medicine at about the same time each day. Talk to your doctor if you are having trouble taking the medication at the suggested time.
